The Rabbit Anti-Superoxide dismutase 1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Rabbit Anti-Superoxide dismutase 1 Antibody has been validated for the following applications: Blotting, Immunofluorescence, and Western Blot.
Description
Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme that catalyzes the dismutation of the superoxide radical O2-to oxygen and hydrogen peroxide which are then metabolized to H2O and O2 by catalase and glutathione peroxidase. SODs play an important role in antioxidant defense mechanisms. SOD1 contains Cu and Zn ions and exists as a homodimer in cell cytoplasm. Each SOD1 monomer folds into an eight-stranded "Greek key" beta-barrel. These strands are connected by seven external loops. Misfolding of SOD1 has been implicated in Amyotrophic Lateral Sclerosis (ALS)